COVID-19 related muscle denervation atrophy
نویسندگان
چکیده
منابع مشابه
Masticator muscle enhancement in subacute denervation atrophy.
Atrophy of the muscles of mastication is a well known indirect sign of damage to the mandibular division of the trigeminal nerve (V3). Because V3 motor palsy is difficult to diagnose clinically, computed tomography (CT) or magnetic resonance (MR) imaging of the head and neck often provide the only evidence of masticator space muscle atrophy (1). This finding, in turn, should alert the physician...
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Muscle inactivity due to injury or disease results in muscle atrophy. The molecular mechanisms contributing to muscle atrophy are poorly understood. However, it is clear that expression of atrophy-related genes, like Atrogin-1 and MuRF-1, are intimately tied to loss of muscle mass. When these atrophy-related genes are knocked out, inactive muscles retain mass. Muscle denervation stimulates musc...
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Denervation leads to the activation of the catabolic pathways, such as the ubiquitin-proteasome and autophagy, resulting in skeletal muscle atrophy and weakness. Furthermore, denervation induces oxidative stress in skeletal muscle, which is thought to contribute to the induction of skeletal muscle atrophy. Several muscle diseases are characterized by denervation, but the molecular pathways cont...
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Myostatin is hypothesized to regulate skeletal muscle mass and to be a potential target for therapeutic intervention in sarcopenia. To clarify whether myostatin is invariably associated with sarcopenia, this study examined the levels of expression of myostatin mRNA and protein in Sprague Dawley rats during aging- and denervation-induced sarcopenia. The level of myostatin mRNA in the gastrocnemi...
متن کاملSkeletal muscle denervation causes skeletal muscle atrophy through a pathway that involves both Gadd45a and HDAC4.
Skeletal muscle denervation causes muscle atrophy via complex molecular mechanisms that are not well understood. To better understand these mechanisms, we investigated how muscle denervation increases growth arrest and DNA damage-inducible 45α (Gadd45a) mRNA in skeletal muscle. Previous studies established that muscle denervation strongly induces Gadd45a mRNA, which increases Gadd45a, a small m...
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ژورنال
عنوان ژورنال: Skeletal Radiology
سال: 2021
ISSN: 0364-2348,1432-2161
DOI: 10.1007/s00256-021-03721-y